Positive regulation of cell proliferation involved in heart morphogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell proliferation involved in heart morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX9, PAXBP1, and ARSK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell proliferation involved in heart morphogenesis activity versus SOX9 in OV (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SOX9 →	+1.319	+0.293	<.001	.004	3	5
UCEC	PAXBP1 →	+0.458	+0.237	.002	<.001	3	5
GBM	ARSK →	+0.305	+0.983	.003	<.001	3	5
GBM	RPS2P16 →	+0.301	+0.697	.001	.002	3	5
UCEC	ZMYM4 →	+0.344	+0.175	.005	.002	3	5
UCEC	DAXX →	+0.761	+0.137	.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000138 vs SOX9 — OV

Explore this scatter interactively →