Positive regulation of cell proliferation involved in heart morphogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell proliferation involved in heart morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM193B, SNRPN, and PANX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM193B grouped by Positive regulation of cell proliferation involved in heart morphogenesis-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FAM193B →	+0.622	+0.206	.003	.006	3	3
CNS	SNRPN →	-1.878	-0.139	.004	.002	3	3
BLOOD_Lymphoma	PANX1 →	+1.432	+0.398	.006	.009	3	3
LUNG_SCLC	CCDC90B →	+0.985	+0.154	.001	.005	3	3
SOFT_TISSUE	ZNF488 →	+2.003	+0.215	.002	.004	3	3
SOFT_TISSUE	GTF2H3 →	-0.459	-0.159	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM193B by Positive regulation of cell proliferation involved in heart morphogenesis activity — BONE

Explore this box plot interactively →