Positive regulation of cell proliferation involved in heart morphogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell proliferation involved in heart morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMA3, LAMA4, and ADAM8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell proliferation involved in heart morphogenesis activity versus LAMA3 in STOMACH (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LAMA3 →	-2.959	-1.383	.009	.001	3	4
LUNG_SCLC	LAMA4 →	-1.211	-0.429	.004	.008	3	4
UPPER_AERODIGESTIVE_TRACT	ADAM8 →	-3.393	-2.048	.003	.001	2	5
BLOOD_Lymphoma	CLN5 →	-0.474	-0.151	.008	<.001	3	3
BLOOD_Lymphoma	ADCK2 →	+1.365	+0.209	<.001	<.001	3	3
LUNG_NSCLC_LUAD	HPS6 →	+0.720	+0.751	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000138 vs LAMA3 — STOMACH

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