Positive regulation of cell proliferation involved in heart morphogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell proliferation involved in heart morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NACA, BTF3, and RPS28, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell proliferation involved in heart morphogenesis activity versus NACA in URINARY_TRACT (Pearson r = 0.93).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NACA →	+2.966	+1.949	.002	<.001	3	15
STOMACH	BTF3 →	+2.350	+1.474	<.001	<.001	3	15
URINARY_TRACT	RPS28 →	+1.923	+2.003	.002	<.001	2	15
URINARY_TRACT	EIF3G →	+1.896	+1.954	.004	<.001	3	14
STOMACH	PTGES3 →	+2.266	+1.416	.002	.002	3	13
STOMACH	RPS14 →	+1.364	+1.422	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000138 vs NACA — URINARY_TRACT

Explore this scatter interactively →