Regulation of removal of superoxide radicals

Across TCGA patient cohorts, RNA activity of the Regulation of removal of superoxide radicals pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LMOD1, TIMP2, and VCL, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of removal of superoxide radicals activity versus LMOD1 in COAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LMOD1 →	+0.743	+0.066	<.001	<.001	3	8
BRCA	TIMP2 →	+0.470	+0.057	<.001	<.001	3	7
COAD	VCL →	+0.369	+0.042	<.001	<.001	3	7
COAD	VWA1 →	+0.377	+0.056	<.001	<.001	3	7
OV	CD36 →	+1.004	+0.081	<.001	<.001	3	7
OV	ADH1B →	+1.331	+0.073	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000121 vs LMOD1 — COAD

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