Negative regulation of macrophage apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of macrophage apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPC, IFI44L, and MTMR3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of macrophage apoptotic process activity versus CENPC in CCRCC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CENPC →	-0.316	-0.856	.002	.001	3	5
LSCC	IFI44L →	+0.721	+0.230	.006	.006	3	4
CCRCC	MTMR3 →	-0.285	-1.034	<.001	<.001	3	4
CCRCC	SLC2A3P2 →	-0.545	-0.811	.008	.002	3	4
PDAC	ZNF582 →	-0.265	-0.459	.001	.001	3	4
PDAC	ZNF615 →	-0.433	-0.560	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000110 vs CENPC — CCRCC

Explore this scatter interactively →