Negative regulation of macrophage apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of macrophage apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WASF3, NAGS, and EIF6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WASF3 grouped by Negative regulation of macrophage apoptotic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	WASF3 →	+1.714	+0.926	.003	.009	3	4
UPPER_AERODIGESTIVE_TRACT	NAGS →	-1.326	-1.257	<.001	.002	3	3
SOFT_TISSUE	EIF6 →	+1.273	+1.585	<.001	<.001	3	3
BREAST	CPNE1 →	+0.805	+0.681	<.001	.004	3	3
SOFT_TISSUE	TTLL1 →	-0.922	-1.220	<.001	.003	3	3
SOFT_TISSUE	PALD1 →	-3.025	-1.549	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WASF3 by Negative regulation of macrophage apoptotic process activity — LUNG_SCLC

Explore this box plot interactively →