Regulation of macrophage apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of macrophage apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGKJ1, PTTG2, and IRF4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macrophage apoptotic process activity versus IGKJ1 in LSCC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IGKJ1 →	+0.857	+0.678	<.001	<.001	3	5
LSCC	PTTG2 →	+0.478	+0.660	<.001	<.001	3	5
LSCC	IRF4 →	+0.785	+0.604	<.001	<.001	3	4
LUAD	RPUSD2 →	-0.286	-0.436	.001	.004	3	4
LSCC	IGKV2D-28 →	+1.829	+0.708	<.001	<.001	3	4
LSCC	POU2F2 →	+0.685	+0.633	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000109 vs IGKJ1 — LSCC

Explore this scatter interactively →