Regulation of macrophage apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of macrophage apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MATN4, SYDE2, and SLC6A6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macrophage apoptotic process activity versus MATN4 in CNS (Pearson r = -0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MATN4 →	-0.163	-1.763	<.001	.003	3	3
CNS	SYDE2 →	-1.270	-1.543	.001	.008	3	3
BLOOD_Myeloma	SLC6A6 →	-2.495	-0.712	.002	<.001	3	3
LUNG_SCLC	LMO1 →	+1.913	+0.903	.005	.005	3	3
BLOOD_Myeloma	CD300A →	-4.056	-0.718	<.001	.001	3	3
LUNG_SCLC	SLC4A11 →	-4.115	-1.265	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000109 vs MATN4 — CNS

Explore this scatter interactively →