Positive regulation of leukocyte apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of leukocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIMAP4, CSF2RB, and CXorf21, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of leukocyte apoptotic process activity versus GIMAP4 in SKCM (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GIMAP4 →	+1.606	+0.047	<.001	<.001	3	33
CHOL	CSF2RB →	+1.675	+0.046	<.001	<.001	3	32
SCLC	CXorf21 →	+1.191	+0.123	<.001	<.001	3	32
DLBC	FGD2 →	+1.422	+0.077	<.001	.001	3	32
DLBC	SLFN5 →	+1.829	+0.070	<.001	<.001	3	32
DLBC	RNF213 →	+1.902	+0.081	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000108 vs GIMAP4 — SKCM

Explore this scatter interactively →