Negative regulation of leukocyte apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of leukocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC8, ABCD3, and ATP5IF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte apoptotic process activity versus DNAJC8 in LUAD (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DNAJC8 →	-0.318	-0.853	<.001	<.001	3	6
CCRCC	ABCD3 →	-0.371	-1.044	.002	<.001	3	5
GBM	ATP5IF1 →	-0.437	-0.569	<.001	<.001	3	5
PDAC	CACFD1 →	-0.381	-0.146	.002	.003	3	5
GBM	ADGRE2 →	+0.625	+0.491	.001	.001	3	5
GBM	NUDT21 →	-0.319	-0.350	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000107 vs DNAJC8 — LUAD

Explore this scatter interactively →