Negative regulation of leukocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of leukocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAS2R43, OAT, and SPOP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAS2R43 grouped by Negative regulation of leukocyte apoptotic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TAS2R43 →	-0.103	-0.576	.004	.002	3	4
LUNG_SCLC	OAT →	-1.186	-0.337	.004	.007	3	3
SOFT_TISSUE	SPOP →	-0.789	-0.969	<.001	.001	3	3
BREAST	VPS13C →	-0.802	-0.619	.009	.007	3	3
BREAST	GLTP →	-0.668	-0.576	.009	.005	3	3
SKIN	ZNF496 →	+0.472	+0.536	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAS2R43 by Negative regulation of leukocyte apoptotic process activity — OVARY

Explore this box plot interactively →