Negative regulation of leukocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of leukocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMD9, FGD6, and ZSWIM3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte apoptotic process activity versus SAMD9 in OVARY (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SAMD9 →	-2.035	-0.243	<.001	<.001	3	5
LARGE_INTESTINE	FGD6 →	-1.045	-0.136	.003	.003	3	5
OVARY	ZSWIM3 →	-1.009	-0.234	<.001	<.001	3	4
BREAST	HSD17B10 →	+1.065	+0.210	<.001	<.001	3	4
STOMACH	THYN1 →	-1.058	-0.230	.006	.003	3	4
LUNG_SCLC	NDUFS7 →	+0.611	+0.209	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000107 vs SAMD9 — OVARY

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