Regulation of leukocyte apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of leukocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FNBP1L, ZKSCAN1, and SOS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of leukocyte apoptotic process activity versus FNBP1L in GBM (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FNBP1L →	-0.972	-0.628	<.001	<.001	3	7
LSCC	ZKSCAN1 →	-0.444	-1.084	<.001	<.001	3	7
BRCA	SOS2 →	-0.482	-0.727	<.001	.002	3	6
HNSC	HMGCS1 →	-0.884	-0.796	<.001	.007	3	6
CCRCC	FCGR1B →	+0.565	+1.264	<.001	<.001	3	6
HNSC	SLC15A3 →	+0.927	+0.808	<.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000106 vs FNBP1L — GBM

Explore this scatter interactively →