Regulation of leukocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS3, ANXA1, and LMNA, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of leukocyte apoptotic process activity versus LGALS3 in BLOOD_Lymphoma (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LGALS3 →	+4.419	+0.393	<.001	<.001	3	11
SOFT_TISSUE	ANXA1 →	+4.548	+0.369	<.001	<.001	3	9
BLOOD_Leukemia	LMNA →	+2.396	+0.204	<.001	.001	3	8
OESOPHAGUS	EPS8 →	+2.500	+0.314	<.001	.003	3	7
LUNG_NSCLC_LUSC	CLCF1 →	+2.099	+0.340	.001	.006	3	6
CNS	SGMS2 →	+1.414	+0.391	.003	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000106 vs LGALS3 — BLOOD_Lymphoma

Explore this scatter interactively →