Positive regulation of DNA-templated DNA replication

Across TCGA patient cohorts, RNA activity of the Positive regulation of DNA-templated DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FPR1, TCTN1, and RBMS1P1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA-templated DNA replication activity versus FPR1 in GBM (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FPR1 →	-1.362	-0.790	<.001	<.001	3	5
HNSC	TCTN1 →	+0.484	+0.333	.001	.003	3	4
OV	RBMS1P1 →	-0.678	-0.290	.002	.005	3	4
LSCC	NONO →	+0.584	+0.573	<.001	.009	3	4
UCEC	MS4A4A →	-0.621	-0.288	<.001	.008	3	4
UCEC	DPP4 →	-1.350	-0.449	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000105 vs FPR1 — GBM

Explore this scatter interactively →