Positive regulation of DNA-templated DNA replication

Across TCGA cell cohorts, RNA activity of the Positive regulation of DNA-templated DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENDOG, SND1, and ADAMTS13, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA-templated DNA replication activity versus ENDOG in SOFT_TISSUE (Pearson r = -0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ENDOG →	-1.106	-0.125	<.001	.002	3	6
LUNG_SCLC	SND1 →	+0.529	+0.104	.004	.002	3	6
OVARY	ADAMTS13 →	-1.346	-0.161	<.001	<.001	3	5
SKIN	CTC1 →	-0.832	-0.124	.001	.002	3	5
OESOPHAGUS	RCOR2 →	-1.265	-0.075	.003	.001	3	5
BREAST	ST3GAL4 →	+1.377	+0.146	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000105 vs ENDOG — SOFT_TISSUE

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