Negative regulation of DNA-templated DNA replication

Across TCGA cell cohorts, RNA activity of the Negative regulation of DNA-templated DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCBTB1, CARD8, and SNX9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of DNA-templated DNA replication activity versus RCBTB1 in OESOPHAGUS (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RCBTB1 →	+0.813	+1.314	<.001	.001	3	5
LUNG_NSCLC_LUSC	CARD8 →	+1.494	+1.534	.009	.009	3	4
LUNG_NSCLC_LUSC	SNX9 →	+0.990	+1.930	.005	<.001	3	4
LUNG_NSCLC_LUSC	C16orf74 →	-1.940	-1.377	.009	.008	2	5
OESOPHAGUS	NDUFS1 →	+0.948	+1.159	.002	.002	3	4
BLOOD_Leukemia	BCL9 →	+1.602	+0.762	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000104 vs RCBTB1 — OESOPHAGUS

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