"Positive regulation of Wnt signaling pathway, planar cell polarity pathway"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of Wnt signaling pathway, planar cell polarity pathway" pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADD1, DLG4_S295, and MAP2_S833, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of Wnt signaling pathway, planar cell polarity pathway" activity versus ADD1 in UCEC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADD1 →	+0.310	+0.087	<.001	.003	3	7
GBM	DLG4_S295 →	+0.759	+0.086	.002	.002	3	6
GBM	MAP2_S833 →	+0.773	+0.091	.001	<.001	3	6
LUAD	ADD3 →	+0.268	+0.058	.002	.008	3	6
PDAC	CYGB →	+0.254	+0.058	.001	<.001	3	6
UCEC	DDAH2 →	+0.378	+0.113	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000096 vs ADD1 — UCEC

Explore this scatter interactively →