"Positive regulation of Wnt signaling pathway, planar cell polarity pathway"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of Wnt signaling pathway, planar cell polarity pathway" pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YIPF5, CTBS, and DAB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of Wnt signaling pathway, planar cell polarity pathway" activity versus YIPF5 in LSCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	YIPF5 →	+0.333	+0.260	<.001	.003	3	5
GBM	CTBS →	+0.365	+0.494	<.001	.007	3	4
LSCC	DAB2 →	+0.689	+0.303	.001	<.001	3	4
GBM	PROS1 →	+0.843	+0.496	.002	.002	2	5
GBM	HEXB →	+0.460	+0.505	<.001	.005	3	4
OV	PLEKHA4 →	+1.012	+0.562	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000096 vs YIPF5 — LSCC

Explore this scatter interactively →