"Positive regulation of Wnt signaling pathway, planar cell polarity pathway"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of Wnt signaling pathway, planar cell polarity pathway" pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLLT3, GPC3, and DKK1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MLLT3 grouped by "Positive regulation of Wnt signaling pathway, planar cell polarity pathway"-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MLLT3 →	-0.208	-1.185	.004	.005	3	9
BREAST	GPC3 →	-0.336	-0.821	.001	.001	3	7
SKIN	DKK1 →	-0.265	-1.243	<.001	.001	3	6
LUNG_NSCLC_LUSC	CD6 →	-0.178	-1.068	.002	<.001	3	6
LUNG_NSCLC_LUAD	VSTM5 →	-0.229	-0.606	<.001	.003	3	5
CNS	RSPO3 →	-0.167	-0.888	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MLLT3 by "Positive regulation of Wnt signaling pathway, planar cell polarity pathway" activity — OVARY

Explore this box plot interactively →