Regulation of cortisol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of cortisol biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STARD10, RBM25, and SRPK1_S311, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cortisol biosynthetic process activity versus STARD10 in BRCA (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STARD10 →	+0.538	+0.040	<.001	.002	3	6
LSCC	RBM25 →	-0.182	-0.070	<.001	<.001	3	6
LSCC	SRPK1_S311 →	-0.536	-0.102	<.001	<.001	3	5
LSCC	WNT4 →	+0.997	+0.072	<.001	.002	3	5
UCEC	STXBP1 →	+0.525	+0.073	.001	.003	3	5
LSCC	EIF2S2 →	-0.137	-0.069	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000064 vs STARD10 — BRCA

Explore this scatter interactively →