Regulation of cortisol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of cortisol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFHC1, PCID2, and JAK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EFHC1 grouped by Regulation of cortisol biosynthetic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	EFHC1 →	+0.894	+1.223	<.001	.003	3	5
BLOOD_Myeloma	PCID2 →	+0.906	+1.269	.003	.002	3	4
SOFT_TISSUE	JAK1 →	+1.413	+1.035	.006	.007	3	4
LUNG_NSCLC_LUSC	ESR2 →	+0.378	+1.808	<.001	<.001	3	4
BLOOD_Leukemia	TYMS →	+0.765	+1.141	.003	.006	3	4
BLOOD_Leukemia	KDM1A →	+1.179	+1.252	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EFHC1 by Regulation of cortisol biosynthetic process activity — BLOOD_Myeloma

Explore this box plot interactively →