Positive regulation of ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of ubiquitin-dependent protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP7, MAP1A, and RAB3D, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ubiquitin-dependent protein catabolic process activity versus FKBP7 in OV (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FKBP7 →	+0.582	+0.043	<.001	<.001	3	8
COAD	MAP1A →	+0.430	+0.033	<.001	<.001	3	8
OV	RAB3D →	-0.676	-0.043	.004	<.001	3	8
OV	C1QC →	+0.820	+0.051	.001	<.001	3	7
CCRCC	C8A →	+0.532	+0.024	<.001	.004	3	7
OV	CAVIN3 →	+0.582	+0.032	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000060 vs FKBP7 — OV

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