Positive regulation of ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGSF9, FASTKD1, and RMND5A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ubiquitin-dependent protein catabolic process activity versus IGSF9 in LSCC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IGSF9 →	-1.227	-0.140	<.001	<.001	3	5
LSCC	FASTKD1 →	-0.377	-0.103	<.001	<.001	3	5
LSCC	RMND5A →	-0.678	-0.154	<.001	<.001	3	5
LSCC	CAMSAP3 →	-0.810	-0.141	<.001	<.001	3	5
GBM	EZH2 →	-0.824	-0.083	.001	.007	3	4
LSCC	YEATS2 →	-0.580	-0.104	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000060 vs IGSF9 — LSCC

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