Positive regulation of ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL22, WASF3, and MIF4GD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPL22 grouped by Positive regulation of ubiquitin-dependent protein catabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MRPL22 →	-0.966	-0.180	.004	.005	3	5
STOMACH	WASF3 →	-1.600	-0.151	.005	.001	3	5
OVARY	MIF4GD →	+0.894	+0.199	<.001	<.001	3	4
BLOOD_Myeloma	MED22 →	-1.032	-0.162	.005	.009	3	4
STOMACH	ADRM1 →	-1.083	-0.198	<.001	<.001	3	4
STOMACH	RPP30 →	-0.805	-0.202	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPL22 by Positive regulation of ubiquitin-dependent protein catabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →