Negative regulation of ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of ubiquitin-dependent protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are POGZ, OGT, and RIF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ubiquitin-dependent protein catabolic process activity versus POGZ in HNSC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	POGZ →	+0.301	+0.070	<.001	.004	3	6
OV	OGT →	+0.202	+0.027	.008	.009	3	5
LSCC	RIF1 →	+0.373	+0.032	.004	.001	3	5
HNSC	WRNIP1 →	+0.288	+0.063	.001	.002	3	5
LSCC	DHX8 →	+0.201	+0.029	.003	<.001	3	5
HNSC	C1orf35 →	+0.411	+0.079	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000059 vs POGZ — HNSC

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