Negative regulation of ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of ubiquitin-dependent protein catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRWD1, SLC39A5, and ZNF701, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRWD1 grouped by Negative regulation of ubiquitin-dependent protein catabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GRWD1 →	+0.258	+0.401	.001	.004	3	5
SOFT_TISSUE	SLC39A5 →	+0.248	+0.245	.009	.001	3	5
BREAST	ZNF701 →	+0.273	+0.109	<.001	<.001	3	5
PANCREAS	AHR →	+0.139	+0.218	.004	.006	3	4
STOMACH	PPIL3 →	+0.341	+0.195	<.001	.004	3	4
LUNG_SCLC	CFHR1 →	+0.194	+0.284	.007	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRWD1 by Negative regulation of ubiquitin-dependent protein catabolic process activity — LIVER

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