Negative regulation of ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAB39L, MIER2, and WDR77, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAB39L grouped by Negative regulation of ubiquitin-dependent protein catabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CAB39L →	+0.945	+0.120	.004	.008	3	5
BLOOD_Myeloma	MIER2 →	+2.204	+0.369	<.001	<.001	3	5
BLOOD_Myeloma	WDR77 →	-1.500	-0.345	.003	.002	3	4
BLOOD_Myeloma	UQCC2 →	-0.733	-0.291	.001	.004	3	4
BLOOD_Myeloma	MRTO4 →	-1.698	-0.417	<.001	<.001	3	4
BLOOD_Myeloma	CAD →	-0.874	-0.371	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAB39L by Negative regulation of ubiquitin-dependent protein catabolic process activity — BREAST

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