Regulation of ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of ubiquitin-dependent protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B, DBN1, and SAMD4B_S557, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ubiquitin-dependent protein catabolic process activity versus MAP1B in LSCC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B →	+0.744	+0.027	.001	.001	3	7
CCRCC	DBN1 →	+0.430	+0.030	<.001	<.001	3	7
CCRCC	SAMD4B_S557 →	+0.227	+0.019	<.001	<.001	3	7
CCRCC	SERPING1 →	+0.544	+0.024	<.001	<.001	3	6
OV	CNN3 →	+0.563	+0.034	.005	.002	3	6
CCRCC	DPYSL3 →	+0.625	+0.034	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000058 vs MAP1B — LSCC

Explore this scatter interactively →