Regulation of ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of ubiquitin-dependent protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RHBDF1_S346, RPL39, and TADA3_S298, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ubiquitin-dependent protein catabolic process activity versus RHBDF1_S346 in OV (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RHBDF1_S346 →	-1.373	-0.209	.001	.002	3	2
OV	RPL39 →	-1.482	-0.245	<.001	<.001	3	2
OV	TADA3_S298 →	+2.428	+0.196	<.001	<.001	3	2
OV	HEATR6_S643 →	-1.468	-0.203	<.001	<.001	3	2
OV	ARHGEF2_S129 →	-2.066	-0.228	<.001	<.001	3	2
COAD	RIN3_S523 →	-0.635	-0.318	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000058 vs RHBDF1_S346 — OV

Explore this scatter interactively →