Regulation of ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC25A, RNASET2, and TPX2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC25A grouped by Regulation of ubiquitin-dependent protein catabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CDC25A →	-0.674	-0.226	.006	.001	3	5
SKIN	RNASET2 →	+1.101	+0.171	.002	.004	3	5
PANCREAS	TPX2 →	-0.689	-0.189	.004	<.001	3	5
URINARY_TRACT	RACGAP1 →	-1.299	-0.263	.006	<.001	3	5
STOMACH	TP53INP1 →	+1.943	+0.203	<.001	<.001	3	5
OVARY	TTC39A →	+1.708	+0.179	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC25A by Regulation of ubiquitin-dependent protein catabolic process activity — LUNG_NSCLC_LUSC

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