Regulation of ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUVBL1, MAIP1, and RSL1D1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ubiquitin-dependent protein catabolic process activity versus RUVBL1 in KIDNEY (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RUVBL1 →	+1.256	+0.286	.006	.005	3	7
BREAST	MAIP1 →	+0.909	+0.206	<.001	<.001	3	7
PANCREAS	RSL1D1 →	+0.897	+0.231	<.001	<.001	3	6
OVARY	FTSJ3 →	+0.931	+0.141	.001	.004	3	5
KIDNEY	MRPS9 →	+0.853	+0.206	.002	.008	3	5
LUNG_SCLC	TFAP4 →	+0.566	+0.124	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000058 vs RUVBL1 — KIDNEY

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