Positive regulation of cell-cell adhesion mediated by cadherin

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell-cell adhesion mediated by cadherin pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SVIL_S549, MAMDC2, and MSRB3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell-cell adhesion mediated by cadherin activity versus SVIL_S549 in HNSC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SVIL_S549 →	+0.822	+0.093	<.001	.001	3	6
BRCA	MAMDC2 →	+0.667	+0.050	<.001	<.001	3	6
BRCA	MSRB3 →	+0.516	+0.039	<.001	<.001	3	6
BRCA	PRKG1 →	+0.675	+0.069	<.001	<.001	3	6
UCEC	ITGA1 →	+0.707	+0.119	.002	<.001	3	6
BRCA	ATAD2 →	-0.544	-0.046	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000049 vs SVIL_S549 — HNSC

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