Positive regulation of cell-cell adhesion mediated by cadherin

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell-cell adhesion mediated by cadherin pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBL1, SIGLEC14, and NRROS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell-cell adhesion mediated by cadherin activity versus RBL1 in OV (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RBL1 →	-0.674	-0.689	.001	.003	3	5
GBM	SIGLEC14 →	-0.789	-0.598	.008	.003	3	5
HNSC	NRROS →	-0.595	-0.621	.004	.002	3	5
GBM	DOK3 →	-0.790	-0.826	<.001	.001	3	5
GBM	ARRB2 →	-0.363	-0.501	.001	.002	3	5
GBM	NCF1 →	-0.324	-0.537	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000049 vs RBL1 — OV

Explore this scatter interactively →