Positive regulation of cell-cell adhesion mediated by cadherin

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell-cell adhesion mediated by cadherin pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS21, DPH6, and DGAT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS21 grouped by Positive regulation of cell-cell adhesion mediated by cadherin-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RPS21 →	+0.957	+1.302	.007	.003	3	4
BLOOD_Leukemia	DPH6 →	-1.051	-1.358	<.001	.002	3	4
OESOPHAGUS	DGAT1 →	-1.004	-0.997	.001	.003	3	4
BREAST	RRAS2 →	-1.698	-0.797	<.001	<.001	3	4
BREAST	IRX3 →	+1.397	+0.699	<.001	.002	3	4
BREAST	CFB →	-1.536	-0.754	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS21 by Positive regulation of cell-cell adhesion mediated by cadherin activity — SOFT_TISSUE

Explore this box plot interactively →