Positive regulation of cell-cell adhesion mediated by cadherin

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell-cell adhesion mediated by cadherin pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THEMIS2, DPH5, and TBL1X, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell-cell adhesion mediated by cadherin activity versus THEMIS2 in LARGE_INTESTINE (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	THEMIS2 →	+1.064	+0.762	.005	.008	2	4
SOFT_TISSUE	DPH5 →	-1.036	-0.313	.005	.003	2	4
STOMACH	TBL1X →	-1.248	-0.306	<.001	.002	3	3
LUNG_NSCLC_LUSC	NOC4L →	+0.793	+0.405	<.001	.006	3	3
UPPER_AERODIGESTIVE_TRACT	CEP57 →	-1.663	-0.476	.001	.006	3	3
SKIN	PHPT1 →	-0.934	-1.366	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000049 vs THEMIS2 — LARGE_INTESTINE

Explore this scatter interactively →