Negative regulation of cell-cell adhesion mediated by cadherin

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell-cell adhesion mediated by cadherin pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VEGFA, PPM1F, and LMNTD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VEGFA grouped by Negative regulation of cell-cell adhesion mediated by cadherin-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	VEGFA →	-0.585	-1.311	.003	.002	3	7
OVARY	PPM1F →	-0.314	-1.106	<.001	<.001	3	6
SKIN	LMNTD1 →	-0.150	-1.341	<.001	<.001	3	5
LARGE_INTESTINE	NOTCH4 →	-0.152	-0.588	<.001	.003	3	5
STOMACH	AK4 →	-0.247	-1.274	<.001	.001	3	4
CNS	DCAF7 →	-0.440	-1.342	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VEGFA by Negative regulation of cell-cell adhesion mediated by cadherin activity — SOFT_TISSUE

Explore this box plot interactively →