Negative regulation of cell-cell adhesion mediated by cadherin

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell-cell adhesion mediated by cadherin pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NSRP1, DEPDC5, and COX6C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NSRP1 grouped by Negative regulation of cell-cell adhesion mediated by cadherin-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NSRP1 →	+0.495	+1.146	.004	<.001	3	4
LARGE_INTESTINE	DEPDC5 →	+0.620	+0.903	.004	.001	3	3
OESOPHAGUS	COX6C →	+0.716	+1.669	<.001	<.001	3	3
LARGE_INTESTINE	PRR14L →	+0.647	+0.637	<.001	.003	3	3
LARGE_INTESTINE	EIF4ENIF1 →	+0.525	+0.677	<.001	.001	3	3
BLOOD_Lymphoma	VCPIP1 →	-0.999	-1.534	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NSRP1 by Negative regulation of cell-cell adhesion mediated by cadherin activity — PANCREAS

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