Negative regulation of cell-cell adhesion mediated by cadherin

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell-cell adhesion mediated by cadherin pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN7, TMEM144, and NXT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell-cell adhesion mediated by cadherin activity versus CLDN7 in OVARY (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CLDN7 →	+4.788	+1.432	<.001	<.001	3	5
BLOOD_Leukemia	TMEM144 →	+1.073	+1.292	.009	<.001	3	5
BLOOD_Lymphoma	NXT1 →	+0.793	+1.294	.007	.002	3	4
BLOOD_Leukemia	SULT1A3 →	-1.254	-1.260	.004	.001	3	4
OESOPHAGUS	H2AC14 →	-1.358	-1.286	.002	.001	3	4
KIDNEY	PEX12 →	-0.586	-1.793	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000048 vs CLDN7 — OVARY

Explore this scatter interactively →