Regulation of cell-cell adhesion mediated by cadherin

Across TCGA patient cohorts, RNA activity of the Regulation of cell-cell adhesion mediated by cadherin pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCDH12, NOTCH4, and PDGFB, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell-cell adhesion mediated by cadherin activity versus PCDH12 in TGCT (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	PCDH12 →	+1.204	+0.073	<.001	<.001	3	31
KIRC	NOTCH4 →	+1.191	+0.051	<.001	<.001	3	30
THYM	PDGFB →	+1.344	+0.095	<.001	<.001	3	29
UCS	HSPG2 →	+1.930	+0.059	<.001	.003	1	31
KIRC	DIPK2B →	+1.111	+0.051	<.001	<.001	3	29
KIRC	ZNF366 →	+0.873	+0.038	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000047 vs PCDH12 — TGCT

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