Regulation of cell-cell adhesion mediated by cadherin

Across TCGA patient cohorts, RNA activity of the Regulation of cell-cell adhesion mediated by cadherin pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CALD1_S131, CNPY4, and CYGB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell-cell adhesion mediated by cadherin activity versus CALD1_S131 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CALD1_S131 →	+0.748	+0.047	<.001	<.001	3	7
UCEC	CNPY4 →	+0.602	+0.087	<.001	<.001	3	6
UCEC	CYGB →	+0.581	+0.059	.005	.006	2	7
GBM	LAMB1 →	+0.486	+0.053	<.001	<.001	3	6
GBM	LAMC1 →	+0.658	+0.087	<.001	<.001	3	6
BRCA	NID1 →	+0.519	+0.058	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000047 vs CALD1_S131 — BRCA

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