Regulation of cell-cell adhesion mediated by cadherin

Across TCGA patient cohorts, RNA activity of the Regulation of cell-cell adhesion mediated by cadherin pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP1, USP53, and SH2D4A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell-cell adhesion mediated by cadherin activity versus TJP1 in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TJP1 →	+0.353	+0.304	.008	.008	3	6
UCEC	USP53 →	+0.770	+0.352	.001	.002	3	5
UCEC	SH2D4A →	+0.615	+0.186	.001	.007	3	4
UCEC	RAPGEF2 →	+0.414	+0.349	.001	.002	3	4
CCRCC	AFDN →	+0.569	+0.686	.001	<.001	2	5
UCEC	NAA35 →	+0.353	+0.284	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000047 vs TJP1 — UCEC

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