Regulation of cell-cell adhesion mediated by cadherin

Across TCGA cell cohorts, RNA activity of the Regulation of cell-cell adhesion mediated by cadherin pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGO3, ERI2, and EIF4A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGO3 grouped by Regulation of cell-cell adhesion mediated by cadherin-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AGO3 →	-0.702	-0.883	<.001	.001	3	4
PANCREAS	ERI2 →	+0.641	+0.899	<.001	.007	3	4
BLOOD_Lymphoma	EIF4A2 →	-1.062	-1.408	.001	<.001	3	4
BREAST	TGFB1 →	-1.858	-0.742	.003	.004	3	4
OESOPHAGUS	TUBB →	-0.873	-1.188	<.001	.001	3	4
LARGE_INTESTINE	SLC6A8 →	-1.499	-0.732	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGO3 by Regulation of cell-cell adhesion mediated by cadherin activity — LUNG_SCLC

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