Regulation of cell-cell adhesion mediated by cadherin

Across TCGA cell cohorts, RNA activity of the Regulation of cell-cell adhesion mediated by cadherin pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPCAM, AFDN, and DLG4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell-cell adhesion mediated by cadherin activity versus EPCAM in LUNG_NSCLC_LUAD (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EPCAM →	+3.024	+0.757	<.001	<.001	3	5
LUNG_NSCLC_LUAD	AFDN →	+1.302	+0.802	<.001	.001	3	5
LUNG_NSCLC_LUAD	DLG4 →	-0.882	-0.532	.004	.003	3	5
LUNG_NSCLC_LUAD	GRB7 →	+1.603	+0.587	<.001	.001	3	5
LUNG_NSCLC_LUAD	MACC1 →	+2.055	+0.629	<.001	<.001	3	5
LUNG_NSCLC_LUAD	RNF223 →	+1.144	+0.576	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000047 vs EPCAM — LUNG_NSCLC_LUAD

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