Negative regulation of double-strand break repair via homologous recombination

Across TCGA patient cohorts, RNA activity of the Negative regulation of double-strand break repair via homologous recombination pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TYMS, KNTC1, and SGO1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of double-strand break repair via homologous recombination activity versus TYMS in LUAD (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TYMS →	+0.694	+0.836	<.001	.001	3	7
LUAD	KNTC1 →	+0.522	+0.741	.003	.002	3	7
LUAD	SGO1 →	+0.623	+0.869	<.001	<.001	3	6
LUAD	FANCI →	+0.591	+0.708	.001	.001	3	6
LUAD	MMS22L →	+0.397	+0.633	<.001	.004	3	6
UCEC	ZBTB12 →	+0.504	+0.818	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000042 vs TYMS — LUAD

Explore this scatter interactively →