Regulation of stem cell population maintenance

Across TCGA patient cohorts, RNA activity of the Regulation of stem cell population maintenance pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLA1, HELLS, and KIF11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of stem cell population maintenance activity versus POLA1 in GBM (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	POLA1 →	+0.588	+0.794	.002	.005	3	5
GBM	HELLS →	+1.123	+0.781	<.001	.003	3	5
BRCA	KIF11 →	+0.916	+0.374	<.001	<.001	3	5
GBM	KNTC1 →	+0.978	+0.854	<.001	.003	3	5
LUAD	RPS27AP3 →	+0.542	+0.225	<.001	<.001	2	5
LUAD	CFH →	-0.881	-0.201	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000036 vs POLA1 — GBM

Explore this scatter interactively →