Regulation of stem cell population maintenance

Across TCGA cell cohorts, RNA activity of the Regulation of stem cell population maintenance pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IAH1, SLC25A28, and WASHC4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IAH1 grouped by Regulation of stem cell population maintenance-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	IAH1 →	-0.830	-0.199	<.001	<.001	3	4
LUNG_SCLC	SLC25A28 →	-0.565	-0.152	.008	.007	1	6
OVARY	WASHC4 →	-0.784	-0.253	.005	.002	3	4
LUNG_NSCLC_LUSC	PRPS1 →	-0.980	-0.270	<.001	<.001	3	4
LUNG_NSCLC_LUSC	ZXDA →	-0.746	-0.215	<.001	.009	3	4
BLOOD_Leukemia	HMGCL →	+0.831	+0.190	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IAH1 by Regulation of stem cell population maintenance activity — PANCREAS

Explore this box plot interactively →