Regulation of stem cell population maintenance

Across TCGA cell cohorts, RNA activity of the Regulation of stem cell population maintenance pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POU2F1, FUS, and CLIC1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of stem cell population maintenance activity versus POU2F1 in LUNG_SCLC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	POU2F1 →	+0.903	+0.182	<.001	.002	3	7
BLOOD_Leukemia	FUS →	+0.442	+0.160	.003	.004	3	6
BLOOD_Leukemia	CLIC1 →	-0.550	-0.175	.004	.003	3	6
BLOOD_Leukemia	HSF2 →	+0.940	+0.217	<.001	.001	3	6
BLOOD_Lymphoma	EHMT1 →	+1.105	+0.254	<.001	.001	3	6
BONE	CPSF6 →	+0.838	+0.373	.009	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000036 vs POU2F1 — LUNG_SCLC

Explore this scatter interactively →