Regulation of stem cell division

Across TCGA cell cohorts, RNA activity of the Regulation of stem cell division pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAMPT, PGM3, and GCHFR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of stem cell division activity versus NAMPT in OESOPHAGUS (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NAMPT →	+1.404	+1.737	.005	<.001	3	4
OESOPHAGUS	PGM3 →	+1.258	+1.159	.004	.006	3	4
BLOOD_Myeloma	GCHFR →	-2.357	-1.616	.001	<.001	3	4
BLOOD_Myeloma	TNFRSF13C →	-1.087	-1.616	.001	<.001	3	4
BLOOD_Leukemia	STEAP1 →	+0.885	+0.730	.005	.001	3	4
LUNG_SCLC	MAD2L1 →	-0.707	-1.070	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000035 vs NAMPT — OESOPHAGUS

Explore this scatter interactively →